Facile solvolysis of a surprisingly twisted tertiary amide
نویسندگان
چکیده
منابع مشابه
Facile solvolysis of a surprisingly twisted tertiary amide
A bicyclo[2.2.2]octane derivative containing both a tertiary amide and a methyl ester (1) was shown crystallographically to adopt a conformation in which the amide is in the cis configuration, which is sterically disfavored, but electronically favored. The steric strain induces a significant torsion (15.91) of the amide, thereby greatly increasing the solvolytic lability of the amide to the ext...
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ژورنال
عنوان ژورنال: New Journal of Chemistry
سال: 2016
ISSN: 1144-0546,1369-9261
DOI: 10.1039/c5nj02449h